193 Virgin Olive Oil Benefits Berr, Dement Geriatr Cogn Disord 2009 Berr, Dement Geriatr Cogn Disord 2009 Berr, Dement Geriatr Cogn Disord 2009 Berr, Dement Geriatr Cogn Disord 2009 PREDIMED−NAVARRA, J Nutr Health Aging 2013 Study 0.94 (0.78, 1.13) 0.95 (0.78, 1.15) 0.91 (0.77, 1.09) 0.83 (0.69, 0.99) 0.34 (0.12, 0.97) RR/OR (95% CI) Comparación OO moderate use- Global cognition deficit OO moderate use- Global cognition deficit OO moderate use-Visual memory deficit OO moderate use-Visual memory deficit EVOO randomisation- Mild cognitive decline Olive oil better Olive oil worse 1 .25 .5 2 4 Performed Comparison Study RR (Confidence Interval 95%) Figure 16.2 – Relative risk (RR) for cognitive function decline according to olive oil consumption Source: Berr C, Portet F, Carriere I, Akbaraly TN, Feart C, Gourlet V, et al. Olive oil and cognition: results from the Three-City study. Dement Geriatr Cogn Disord 2009;28(4):357–64. doi: 10.1159/000253483. Figure 16.1 –PREDIMED-NAVARRA trial design Source: Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martinez-Gonzalez MÁ. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry 2013;84(12):1318-25. doi: 10.1136/jnnp-2012-304792. EVOO: Extra virgin olive oil. Mini mental: the most commonly used test to assess cognitive performance. Mediterranean diet +EVOO Low-fat diet (control group) Mediterranean diet +nuts 6.5 year follow-up 6.5 year follow-up 6.5 year follow-up Mini mental clock test Mini mental clock test Mini mental clock test Better Better Rando- misation Researchers from the Navarra vanguard center of PREDIMED (PREDIMED-Navarra) evaluated the cognitive performance of 522 participants after 6.5 years of intervention. Participants in the Mediterranean diet supplemented with EVOO and the n=166 n=132 -o- ~- -( -0- (o 7 1 1
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