• Minor bioactive cornpounds in EVOO, such as polyplzenols, promote gut microbwta cliversity and the growth of beneficial microbial species. This may contribute to irnproved metabolic health, reduced low-grade injlammation, and better weight regulation. • Genetic variability, uch as the PPARG2 Prol 2Ala pofymorph:ism, influences individual re ponses to EVOO. This supports the application of precisi,on nutrition approaches that tailor clietary recommendations based on genetic and metabolic profiles. • Outlook: Ongoing large-scale stuclies, such as PREDIMED Plus, are expected to provide more definitive evidence on the role of EVOO in obesity prevention. The e findings will help refine public health recommendations and guide personalised clietaiy strategies for irnproved metabolic health and body composition. 12.7. References - For further knowledge OrdovasJM, Fergu on LR, Tai ES and MathersJC. Personalised nutrition and health. BMJ 2018;361:bmj k2173 (1-7). Zamora Zamora F, Martinez GalianoJM, Gaforio MartinezJJ and Delgado Rodriguez M. [Olive Oil and Body Weight. Sy tematic Review and Meta-Analysis of Randomized Controlled Trials]. Rev Esp Salud Publica 2018;92: e201811083. Valdes AM, Walter J, Segal E and Spector TD. Role of the gut microbwta in nutrition and health. BMJ 2018;13:361:k2179 (36-44). Corella D, Barragan R, Ordovas JM and Coltell O. [Nutrigenetics, nutrigenomics and Mediterranean diet: a new vision for gastronomy]. utr Hosp 2018;35:19-27. Rodrigue APS, Rosa LPS and Silveira EA. PPARG2 Prol2Ala pofymorphism influences body compo ition change in severely obese patients consuming extra virgin olive oil: a randomized clinical trial. utr Metab 2018;15:52 (1-13). https://doi.org/10.1186/s12986-018-0289-4 0ast acces ed September 2025)
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