331 Virgin Olive Oil Benefits alterations in the chemical composition of the blood. Contributing factors include prolonged immobility (e.g., extended bed rest), or underlying conditions such as diabetes, hypertension, obesity, cancer, or genetic disorders affecting the coagulation system. Other risk factors may affect anyone: advanced age, immobility during long-haul travel, sedentary behaviour, smoking, hormonal changes such as those during pregnancy, oral contraceptive use, or hormone replacement therapy during menopause. Thrombi can form in both arteries and veins. - vascular thrombosis See the introduction to this section. (Related terms on this topic: “Tissue plasminogen activator”, “Plasminogen activator inhibitor”, “Tissue factor”, “Platelet function”, “Haemostasis”, and “Nitric oxide”) THROMBOTIC EVENT (See THROMBOSIS) THROMBOTIC MARKER (See THROMBOSIS) THROMBOXANE/S (See EICOSANOIDS) THROMBUS / THROMBI (See THROMBOSIS) TISSUE FACTOR Also known as thromboplastin, this glycoprotein is normally found in the fibroblasts of blood vessel walls and in many other cell types. It is located in the membranes of these cells. When a blood vessel is ruptured, for example due to a wound, this factor is released from the endothelium and, together with other coagulation factors, contributes to clot formation, sealing the damaged vessel and preventing blood loss. (See also “Haemostasia” and “Platelet Function”) TOCILIZUMAB (See INFLAMMATION) α-TOCOPHEROL (See MINOR COMPOUNDS / Tocopherols) β-TOCOPHEROL (See MINOR COMPOUNDS / Tocopherols) δ-TOCOFEROL (See MINOR COMPOUNDS / Tocopherols) γ- TOCOPHEROL (See MINOR COMPOUNDS / Tocopherols) TOCOPHEROLS (See MINOR COMPOUNDS)
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